Before the development and distribution of COVID-19 vaccines, monoclonal antibodies (mAbs) were considered one of the most effective and widely used therapies to reduce the risk of progression to severe COVID, especially for high-risk patients. Lab-created mAbs seek out foreign materials in the body, such as the COVID-19 virus, and stick to them in order to destroy them.
New research, published in Frontiers in Public Health, from the University of Minnesota School of Public Health (SPH) and several partners traces the development, implementation and health outcomes of Minnesota’s system for distributing mAbs during the COVID-19 pandemic. According to the study, Minnesota’s online platform connected over 31,000 patients to care during its operation, successfully distributing a potentially life-saving treatment to those most eligible to receive treatment — regardless of their connection to a health care system.
A collaboration between the Minnesota Department of Health, the University of Minnesota and 116 private health care administration sites across the state developed an online platform, Minnesota Resource Allocation Platform (MNRAP), which facilitated access to mAbs when supplies were sufficient. When supplies ran low, MNRAP managed the allocation of resources by prioritizing those most at risk for hospitalization or death.
By analyzing the health outcomes of the people who interacted with MNRAP between February 2021 and July 2022, the study found:
There was a statistically significant difference in hospitalizations for people who did not receive a referral through MNRAP versus those who did (5.2% for unreferred versus 6.1% for referred), because those who received referrals were at much higher clinical risk than those that did not.
Vaccination conferred a substantially larger protection against hospitalization and death than did a referral for mAbs, but among unvaccinated users that did not get a referral, chances of hospitalization increased by 4.1%.
Source: umn.edu
Photo Credit: gettyimages-richlegg
Categories: Minnesota, Education, General